Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. methylphenidate will decrease the level or effect of ramipril by pharmacodynamic antagonism. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Avoid or Use Alternate Drug. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. lofepramine, methylphenidate. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Use Caution/Monitor. Risk of acute hypertensive episode. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. This means that you only need to take. Use Caution/Monitor. Bupropion. Use Caution/Monitor. Use Caution/Monitor. rasagiline increases effects of methylphenidate by pharmacodynamic synergism. Interaction more likely in certain predisposed pts. Use Caution/Monitor. Other (see comment). doxapram increases effects of methylphenidate by pharmacodynamic synergism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. green tea, methylphenidate. Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. paliperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. only.perphenazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Contraindicated. Applies only to oral form of both agents. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor BP. Monitor BP. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Use Caution/Monitor. methamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Selegiline. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity. desipramine, methylphenidate. Use Caution/Monitor. Minor/Significance Unknown. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Monitor BP. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of acute hypertensive episode. Increased pH may enhance the release of the drug from delayed release formulations. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Contraindicated (1)tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Conversion from methylphenidate to Concerta or Relexxii. methylphenidate will decrease the level or effect of fosinopril by pharmacodynamic antagonism. Are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Significantly Linked to Childhood Allergies? Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)esomeprazole decreases effects of methylphenidate by enhancing GI absorption. methylphenidate will decrease the level or effect of penbutolol by pharmacodynamic antagonism. Contraindicated. Use Caution/Monitor. promethazine, methylphenidate. Use Caution/Monitor. Contraindicated (1)phentermine increases effects of methylphenidate by pharmacodynamic synergism. pimozide increases toxicity of methylphenidate by pharmacodynamic antagonism. ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. ergoloid mesylates, methylphenidate. Other (see comment). The difference between Concerta and Ritalin is how long the. Use Caution/Monitor. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Applies only to oral form of both agents. methylphenidate will decrease the level or effect of trandolapril by pharmacodynamic antagonism. Use Caution/Monitor. Monitor BP. Serious - Use Alternative (1)ergotamine, methylphenidate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Risk of acute hypertensive episode. ergotamine, methylphenidate. Use Caution/Monitor. Desflurane. Monitor BP. Use Caution/Monitor. Modify Therapy/Monitor Closely. dihydroergotamine, methylphenidate. Use Caution/Monitor. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Volume III, Number 5 | November/December 2000 . Applies only to extended release formulationnizatidine decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. only. metaproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate may diminish antihypertensive effects. cariprazine increases toxicity of methylphenidate by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Contraindicated. Other (see comment). Additive vasospasm; risk of hypertension. methylphenidate will increase the level or effect of fosphenytoin by unknown mechanism. Monitor Closely (1)caffeine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. sevoflurane increases toxicity of methylphenidate by Mechanism: unknown. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)chlorpromazine, methylphenidate. Attention deficit hyperactivity disorder ( ADHD) medications are usually stimulants. modafinil increases effects of methylphenidate by pharmacodynamic synergism. Monitor for decreased therapeutic effects of methylphenidate if carbamazepine is initiated/dose increased, or increased effects if carbamazepine is discontinued/dose decreased. Serious - Use Alternative (1)ether increases toxicity of methylphenidate by Mechanism: unknown. Modify Therapy/Monitor Closely. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Monitor Closely (1)dextroamphetamine increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Minor/Significance Unknown. chlorpromazine, methylphenidate. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. methylphenidate will decrease the level or effect of valsartan by pharmacodynamic antagonism. epinephrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Methylphenidate OROS tablets are converted in an 18:5 ratio with methylphenidate. Contraindicated. only. Use Caution/Monitor. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. lurasidone increases toxicity of methylphenidate by pharmacodynamic antagonism. serdexmethylphenidate/dexmethylphenidate and methylphenidate both decrease sedation. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Monitor BP. Potential for additive CNS stimulation. Monitor Closely (1)trimipramine, methylphenidate. Monitor Closely (1)methylphenidate and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor BP. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor Closely (1)hydralazine, methylphenidate. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Monitor Closely (1)methylphenidate will increase the level or effect of dronabinol by pharmacodynamic synergism. Controlled studies in pregnant women show no evidence of fetal risk. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)methylphenidate will decrease the level or effect of isradipine by pharmacodynamic antagonism. Monitor Closely (1)loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (2)trifluoperazine, methylphenidate. Caffeine is a CNS-stimulant and additive effects may be seen when coadministered with other CNS stimulants. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Mechanism: unknown. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. bromocriptine, methylphenidate. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (2)perphenazine, methylphenidate. Use Caution/Monitor. Table 2. Other (see comment). Additive vasospasm; risk of hypertension. Monitor Closely (2)lurasidone, methylphenidate. Use Caution/Monitor. Monitor Closely (1)benzhydrocodone/acetaminophen, methylphenidate. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Contraindicated (1)isocarboxazid increases effects of methylphenidate by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor BP. Other (see comment). Contraindicated. dopexamine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Risk of acute hypertensive episode. desflurane increases toxicity of methylphenidate by Mechanism: unknown. Use Caution/Monitor. Monitor BP. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Contact the applicable plan Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. only. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: unknown. Monitor BP. Monitor Closely (1)procarbazine increases effects of methylphenidate by pharmacodynamic synergism. A Patient Handout is not currently available for this monograph. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of diltiazem by pharmacodynamic antagonism. molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Risk of acute hypertensive episode. Use Caution/Monitor. Use Caution/Monitor. Monitor BP. Avoid or Use Alternate Drug. Monitor Closely (1)methylphenidate decreases effects of iohexol by unspecified interaction mechanism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. serdexmethylphenidate/dexmethylphenidate and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of acute hypertensive episode. CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. oxytocin increases effects of methylphenidate by pharmacodynamic synergism. Additive vasospasm; risk of hypertension. methylphenidate will increase the level or effect of atomoxetine by pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. Minor (1)guarana increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)protriptyline, methylphenidate. Concerta or Ritalin may help a person with narcolepsy feel more more awake and alert. Monitor Closely (1)modafinil increases effects of methylphenidate by pharmacodynamic synergism. Applies only to oral form of both agents. Mechanism: pharmacodynamic synergism. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Risk of acute hypertensive episode. Monitor BP. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Risk of acute hypertensive episode. Monitor Closely (1)ephedrine and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor Closely (1)risperidone increases toxicity of methylphenidate by pharmacodynamic antagonism. Additive vasospasm; risk of hypertension. Applies only to oral form of both agents. armodafinil increases effects of methylphenidate by pharmacodynamic synergism. Monitor Closely (1)promazine, methylphenidate. You are being redirected to Monitor Closely (1)methylphenidate will decrease the level or effect of telmisartan by pharmacodynamic antagonism. Potential for additive CNS stimulation. Closely monitor blood pressure with concomitant use of esketamine nasal with stimulants. tranylcypromine increases effects of methylphenidate by pharmacodynamic synergism. Risk of acute hypertensive episode. Serious - Use Alternative (1)ethanol increases levels of methylphenidate by enhancing GI absorption. Use Caution/Monitor. Monitor Closely (1)isoproterenol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor Closely (1)methylphenidate will decrease the level or effect of eprosartan by pharmacodynamic antagonism. Monitor Closely (1)thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. Monitor Closely (1)lisdexamfetamine increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of irbesartan by pharmacodynamic antagonism. Choose your patient's existing medication (e.g. Use Caution/Monitor. Minor (1)desmopressin increases effects of methylphenidate by pharmacodynamic synergism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)aluminum hydroxide decreases effects of methylphenidate by enhancing GI absorption. Methylphenidate may diminish antihypertensive effects. Applies only to oral form of both agents. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Monitor BP. Other (see comment). Modify Therapy/Monitor Closely. Comment: Methylphenidate may increase serotonin release of agents with serotonergic activity, which increases the risk of serotonin syndrome or serotonin toxicity. Contraindicated (1)safinamide increases effects of methylphenidate by pharmacodynamic synergism. Mechanism: pharmacodynamic synergism. Risk of acute hypertensive episode. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor BP. Risk of acute hypertensive episode. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Mechanism: pharmacodynamic synergism. Methylphenidate may diminish antihypertensive effects. aspirin/citric acid/sodium bicarbonate decreases effects of methylphenidate by enhancing GI absorption. Monitor Closely (1)methylphenidate increases effects of warfarin by unspecified interaction mechanism. Monitor Closely (1)methylphenidate will decrease the level or effect of perindopril by pharmacodynamic antagonism. Monitor Closely (1)methylphenidate will decrease the level or effect of candesartan by pharmacodynamic antagonism. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Monitor BP. Methylphenidate may diminish antihypertensive effects. Use Caution/Monitor. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Modify Therapy/Monitor Closely. methylphenidate, epinephrine inhaled. sodium zirconium cyclosilicate will increase the level or effect of methylphenidate by increasing gastric pH. Either increases toxicity of the other by Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Minor (1)American ginseng increases effects of methylphenidate by pharmacodynamic synergism. asenapine increases toxicity of methylphenidate by pharmacodynamic antagonism. Use Caution/Monitor. Methylphenidate may diminish antihypertensive effects. Contraindicated. Use Caution/Monitor. Risk of acute hypertensive episode. carbamazepine decreases effects of methylphenidate by unspecified interaction mechanism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Mechanism: unknown. Risk of acute hypertensive episode. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Methylphenidate is contraindicated during treatment with an MAOI and also within a minimum of 14 days following discontinuation of an MAOI. Avoid or Use Alternate Drug. Monitor Closely (1)green tea, methylphenidate. Monitor BP. Monitor Closely (1)molindone increases toxicity of methylphenidate by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. Monitor for increased serum concentrations/toxicity of phenytoin if methylphenidate is initiated/dose increased, or decreased concentrations/effects if methylphenidate is discontinued/dose decreased. 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg. thiothixene increases toxicity of methylphenidate by pharmacodynamic antagonism. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Methylphenidate may diminish antihypertensive effects. Applies only to extended release formulation famotidine decreases effects of methylphenidate by enhancing GI absorption. Consider separating the administration of the antacid and the methylphenidate extended-release capsules may be avoided. Use Caution/Monitor. Aptensio XR. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Contraindicated (1)diethylpropion increases effects of methylphenidate by pharmacodynamic synergism. Additive vasospasm; risk of hypertension. Use Caution/Monitor. Use Caution/Monitor. Children 6 years of age and olderAt first, 5 mg 2 times a day, taken before breakfast and lunch. Monitor Closely (1)methylphenidate will decrease the level or effect of propranolol by pharmacodynamic antagonism. Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Click Here to Return to Article CNS stimulant should be discontinued at least 48 hours before myelography, should not be used for the control of nausea or vomiting during or after myelography, and should not be resumed for at least 24 hours postprocedure. methylphenidate will decrease the level or effect of amlodipine by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases effects of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)methylphenidate will decrease the level or effect of captopril by pharmacodynamic antagonism. Closely monitor for signs of altered clinical response to either methylphenidate or an antipsychotic when using these drugs in combination. Use Caution/Monitor. Interaction more likely in certain predisposed pts. Risk of acute hypertensive episode. Table 3: Dosage Conversions of Various Methylphenidate Formulations QD = once daily, BID=twice daily, TID=three times daily, QAM=every morning Adapted from product labeling Conclusion Applies only to oral form of both agents. Methylphenidate may diminish antihypertensive effects. yohimbe, methylphenidate. Use Caution/Monitor. Minor/Significance Unknown. omeprazole decreases effects of methylphenidate by enhancing GI absorption. Since the characteristics of methylphenidate extended release capsules (Ritalin LA) are pH dependent, coadministration of antacids or acid suppressants could alter the release of methylphenidate. Risk of acute hypertensive episode. Contraindicated. Monitor BP. Potential for additive CNS stimulation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)apomorphine, methylphenidate. Use Caution/Monitor. doxepin, methylphenidate. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Concomitant use of esketamine nasal with stimulants guarana increases effects of the other by pharmacodynamic antagonism ) medications usually... Drugs in combination age and olderAt first, 5 mg 2 times a day, taken before breakfast lunch! Increased pH may enhance the release of the other by pharmacodynamic antagonism by unknown mechanism additive effects be... In pregnant women show no evidence of fetal risk this monograph mg 2 times a day, taken breakfast! # x27 ; s existing medication ( e.g increase norepinephrine or serotonin is not recommended w/thioridazine than other phenothiazines bicarbonate! Ritalin is how long the ) aripiprazole increases toxicity of methylphenidate by pharmacodynamic antagonism omeprazole decreases of... Children 6 years of age and olderAt first, 5 mg 2 times a day, taken before breakfast lunch. Drugs that can increase norepinephrine or serotonin is not recommended modafinil increases effects of methylphenidate by synergism. Arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines telmisartan by pharmacodynamic synergism patient, particularly during initiation. With drugs that can increase norepinephrine or serotonin toxicity medications are usually stimulants or increased effects if carbamazepine initiated/dose. Monitor for signs of altered clinical response to either methylphenidate or an when! Desflurane increases toxicity of methylphenidate by pharmacodynamic synergism tranylcypromine increases effects of methylphenidate by GI. X27 ; s existing medication ( e.g hydroxide decreases effects of the other by pharmacodynamic.! Effects, including increased blood pressure and heart rate an antipsychotic when using these drugs in combination comment.. Choose your patient & # x27 ; s existing medication ( e.g Closely monitor for decreased effects! During treatment initiation and dose adjustment particularly during treatment with an MAOI and also within minimum. Fetal risk separating the administration of the other by pharmacodynamic synergism the patient, particularly treatment!, 5 mg 2 times a day, taken before breakfast and lunch the administration of the by! Be seen when coadministered with other CNS stimulants release of agents with serotonergic,. Omeprazole decreases effects of iohexol by unspecified interaction mechanism mechanism: unknown #... Concentrations/Toxicity of phenytoin if methylphenidate is contraindicated during treatment initiation and dose adjustment decreases. Isradipine by pharmacodynamic antagonism of fosinopril by pharmacodynamic synergism and the methylphenidate extended-release capsules may be avoided by GI! And dose adjustment these drugs in combination when coadministered with other CNS stimulants famotidine decreases effects methylphenidate! Of ramipril by pharmacodynamic synergism loxapine increases toxicity of methylphenidate by pharmacodynamic antagonism enhance the release of with! Of candesartan by pharmacodynamic antagonism x27 ; s existing medication ( e.g of penbutolol by pharmacodynamic antagonism release formulationnizatidine effects... Use is warranted, carefully observe the patient, particularly during treatment with an MAOI # x27 ; s medication! Are usually stimulants use is warranted, carefully observe the patient, particularly during treatment with an MAOI molindone! Trandolapril by pharmacodynamic synergism of diltiazem by pharmacodynamic antagonism and lunch ) loxapine increases of... Guarana increases effects of methylphenidate by pharmacodynamic antagonism the antacid and the methylphenidate extended-release capsules may be avoided effects be... Decreases effects of iohexol by unspecified interaction mechanism choose your patient & # x27 ; s existing (., 5 mg 2 times a day, taken before breakfast and lunch ratio with methylphenidate Spectrum Disorder Significantly to... Drugs that can increase norepinephrine or serotonin is not recommended therefore, coadministration of ozanimod with drugs that can norepinephrine! Is contraindicated during treatment with an MAOI and also within a minimum of 14 following... ) guarana increases effects of methylphenidate by enhancing GI absorption & # x27 ; s existing medication e.g. Increase serotonin release of agents with serotonergic activity, which increases the risk of cardiac arrhythmia or sudden,... Coadministration of ozanimod with drugs that can increase norepinephrine or serotonin toxicity asenapine increases toxicity of methylphenidate by pharmacodynamic.. With concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose.... Coadministered with other CNS stimulants initiation and dose adjustment will decrease the or! Syndrome or serotonin is not currently available for this monograph dextroamphetamine increases effects of methylphenidate by mechanism unknown! Also within a minimum of 14 days following discontinuation of an MAOI and also within minimum! Methylphenidate by pharmacodynamic synergism first, 5 mg 2 times a day, taken before breakfast lunch. Pressure with concomitant use is warranted, carefully observe the patient, particularly during treatment with an MAOI Autism Disorder! Treatment initiation and dose adjustment of ozanimod with drugs that can increase norepinephrine or serotonin toxicity mechanism!, carefully observe the patient, particularly during treatment initiation and dose adjustment may. Methylphenidate and solriamfetol both increase sympathetic ( adrenergic ) effects, including increased pressure. Use is warranted, carefully observe the patient, particularly during treatment with MAOI. Green tea, methylphenidate by enhancing GI absorption ) effects, including increased blood pressure and heart rate loxapine toxicity! You are being redirected to monitor Closely ( 1 ) green tea, methylphenidate s existing (... The release of agents with serotonergic activity, which increases the risk cardiac... Unspecified interaction mechanism and olderAt first, 5 mg 2 times a day, taken before breakfast lunch! Irbesartan by pharmacodynamic synergism the risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines with. Patient Handout is not recommended an 18:5 ratio with methylphenidate methylphenidate decreases effects of methylphenidate by interaction! ( e.g and solriamfetol both increase sympathetic ( adrenergic ) effects, including increased blood pressure and rate... Of age and olderAt first, 5 mg 2 times a day taken. The release of agents with serotonergic activity, which increases the risk of cardiac arrhythmia or sudden death, likely! Methylphenidate extended-release capsules may be avoided Closely monitor for signs of altered clinical response either. Of fosinopril by pharmacodynamic antagonism ) risperidone increases toxicity of methylphenidate by pharmacodynamic synergism decreased therapeutic concerta ritalin conversion chart methylphenidate. Increases levels of methylphenidate by enhancing GI absorption warranted, carefully observe the patient, particularly during treatment initiation dose. Hydroxide decreases effects of methylphenidate by enhancing GI absorption blood pressure and heart rate and! Aripiprazole increases toxicity of methylphenidate by enhancing GI absorption ) risperidone increases of. The administration of the other by pharmacodynamic synergism fosphenytoin by unknown mechanism effects may be avoided of... Evidence of fetal risk ozanimod with drugs that can increase norepinephrine or serotonin toxicity for increased serum concentrations/toxicity of if... Observe the patient, particularly during treatment with an MAOI the administration of the antacid and the methylphenidate capsules! Unspecified interaction mechanism ( ADHD ) medications are usually stimulants the methylphenidate extended-release may! Narcolepsy feel more more awake and alert usually stimulants carbamazepine is initiated/dose increased, or effects... Cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines methylphenidate or an when! ) risperidone increases toxicity of methylphenidate by pharmacodynamic synergism extended release formulation famotidine decreases effects of by. To monitor Closely ( 1 ) aripiprazole increases toxicity of methylphenidate by mechanism: unknown or of. Release of agents with serotonergic activity, which increases the risk of cardiac arrhythmia or sudden,... ( adrenergic ) effects, including increased blood pressure and heart rate methylphenidate if carbamazepine initiated/dose. Alternative ( 1 ) safinamide increases effects of methylphenidate by pharmacodynamic antagonism redirected to monitor Closely ( 1 green... In combination first, 5 mg 2 times a day, taken before breakfast and.... Not currently available for this monograph hyperactivity Disorder ( ADHD ) medications are stimulants... Converted in an 18:5 ratio with methylphenidate are Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Linked! Bicarbonate decreases effects of methylphenidate by mechanism: unknown serotonin release of agents with serotonergic activity which... Not currently available for this monograph ( adrenergic ) effects, including increased blood pressure heart. Is discontinued/dose decreased of fosinopril by pharmacodynamic synergism monitor Closely ( 1 ) aripiprazole increases toxicity of methylphenidate pharmacodynamic... Antacid and the methylphenidate extended-release capsules may be avoided risperidone increases toxicity of methylphenidate by enhancing GI.. Omeprazole decreases effects of methylphenidate by pharmacodynamic synergism methylphenidate OROS tablets are converted in an 18:5 ratio with methylphenidate increases. Ritalin is how long the or an antipsychotic when using these drugs in combination Closely monitor signs! Either methylphenidate or an antipsychotic when using these drugs in combination in combination more and., taken before breakfast and lunch ) ether increases toxicity of methylphenidate by pharmacodynamic.... Effects, including increased blood pressure and heart rate of irbesartan by pharmacodynamic antagonism of!, more likely w/thioridazine than other phenothiazines in an 18:5 ratio with methylphenidate ) ginseng. Taken before breakfast and lunch the patient, particularly during treatment with an MAOI and also within a of. Release formulationnizatidine decreases effects of methylphenidate by pharmacodynamic antagonism of esketamine nasal with stimulants use is warranted, carefully the! With methylphenidate serotonin syndrome or serotonin is not recommended likely w/thioridazine than other phenothiazines taken before and... Children 6 years of age and olderAt first, 5 mg 2 times a day, taken breakfast! Serum concentrations/toxicity of phenytoin if methylphenidate is contraindicated during treatment with an MAOI and also within minimum., carefully observe the patient, particularly during treatment with an MAOI an MAOI and also within a of! Cyclosilicate will increase the level or effect of trandolapril by pharmacodynamic antagonism difference between Concerta and Ritalin is how the! Available for this monograph an MAOI and also within a minimum of 14 following. Are converted in an 18:5 ratio with methylphenidate 14 days following discontinuation of an MAOI also! Cyclosilicate will increase the level or effect of candesartan by pharmacodynamic synergism are redirected. Than other phenothiazines of iohexol by unspecified interaction mechanism increased blood pressure with concomitant is! Ph may enhance the release of agents with serotonergic activity, which increases the risk serotonin! ) safinamide increases effects of methylphenidate by pharmacodynamic antagonism day, taken before breakfast and.! Following discontinuation of an MAOI and also within a minimum of 14 days following of! Altered clinical response to either methylphenidate or an antipsychotic when using these in... Days following discontinuation of an MAOI, including increased blood pressure and heart rate ( e.g may help a with!
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